Nitrogen is a key factor in maize (Zea mays L.) grain and biomass production. Inappropriate application with sub-optimum plant density and irrigation can lead to low productivity and inefficient use. A two-year field experiment was conducted to determine which nitrogen rate, plant density, and irrigation level optimize grain, biomass yield, and water use efficiency. Three nitrogen rates of urea (46–0–0 of N–P2O5–K2O) (N0 = 0 kg N ha-1, N1 = 270 kg N ha-1, and N2 = 360 kg N ha-1), with three maize densities (D1 = 75,000 plants ha-1, D2 = 97,500 plants ha-1, and D3 = 120,000 plants ha-1), and two irrigation levels (W1 = 5250 m3/hm2 and W2 = 4740 m3/hm2) were investigated. The results show that both grain and biomass yields were affected by the main factors. The interaction between nitrogen rate and irrigation level significantly (p < 0.001) affected grain yield but not biomass. It was observed that the grain yield increased correspondingly with nitrogen rate and plant density, while it decreased as the irrigation level increased. Water use efficiency was significantly (p < 0.001) affected by the main factors and their interactions. Nevertheless, water use efficiency was highest at (5250 m3/hm2) × 270 kg N ha-1; × 360 kg N ha-1 × 120,000 plants ha-1 and increased from 62% to 68%. In addition, the highest biomass yield was recorded at 5250 m3/hm2 × 270 kg N ha-1; × 360 kg N ha-1 × 120,000 plants ha-1 while the interaction of either irrigation level with 0 and 270 kg ha-1 or 97,500 and 120,000 plants ha-1 yielded the lowest water use efficiency. Thus, optimized nitrogen rates, plant density, and alternate irrigation levels can support optimum grain and biomass yields. It can also improve nitrogen and water use efficiency in maize production.